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COMPLEMENT C3A
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DeCS
Descriptor
English
:
Complement C3a
Descriptor
Spanish
:
complemento C3a
Descriptor
Portuguese
:
Complemento C3a
Synonyms
English
:
C3a Complement
C3a, Complement
Complement 3a
Complement Component 3a
Complement, C3a
Component 3a, Complement
Tree Number:
D12.776.124.486.274.024.250
D12.776.124.486.274.250.250
Definition
English
:
The smaller fragment generated from the cleavage of
complement C3
by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth
MUSCLE CONTRACTION
, and
HISTAMINE RELEASE
from
MAST CELLS
and
LEUKOCYTES
. C3a is considered an
anaphylatoxin
along with
COMPLEMENT C4A
;
COMPLEMENT C5A
; and
COMPLEMENT C5A
, DES-ARGININE.
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1990)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24575
Unique Identifier:
D015926
Occurrence in VHL
:
Similar:
DeCS